Stem cells in retinal regeneration: past, present and future

Author:

Ramsden Conor M.12,Powner Michael B.1,Carr Amanda-Jayne F.1,Smart Matthew J. K.1,da Cruz Lyndon12,Coffey Peter J.13

Affiliation:

1. The London Project to Cure Blindness, Division of ORBIT, Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK

2. NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, EC1V 2PD, UK

3. Center for Stem Cell Biology and Engineering, NRI, UC Santa Barbara, CA 93106, USA

Abstract

Stem cell therapy for retinal disease is under way, and several clinical trials are currently recruiting. These trials use human embryonic, foetal and umbilical cord tissue-derived stem cells and bone marrow-derived stem cells to treat visual disorders such as age-related macular degeneration, Stargardt's disease and retinitis pigmentosa. Over a decade of analysing the developmental cues involved in retinal generation and stem cell biology, coupled with extensive surgical research, have yielded differing cellular approaches to tackle these retinopathies. Here, we review these various stem cell-based approaches for treating retinal diseases and discuss future directions and challenges for the field.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

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