RUNX transcription factors: orchestrators of development

Author:

Mevel Renaud1,Draper Julia E.1ORCID,Lie-a-Ling Michael1,Kouskoff Valerie2ORCID,Lacaud Georges1ORCID

Affiliation:

1. Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, Alderley Edge, Macclesfield SK10 4TG, UK

2. Division of Developmental Biology & Medicine, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK

Abstract

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.

Funder

Medical Research Council

Biotechnology and Biological Sciences Research Council

Horizon 2020

Cancer Research UK

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

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