Pharmaceutical Benefits of Natural Products

Abstract

Angiogenesis is the process by which new blood vessels are created from existing endothelial cells. Vascular endothelial growth factor (VEGF) is the primary regulator of endothelial cells (ECs), which are the biological components of freshly created capillaries. The drugs currently available are synthetic or humanised monoclonal antibodies, which are toxic and expensive. Natural therapies and compounds originating from plants, aquatic animals, and microbes are already being used to enhance conventional treatment for a variety of angiogenic illnesses, including cancer. The EGF, VEGF receptor, protein kinases, cyclooxygenase-2, HER2/neu gene, Bcl-2, coagulation pathways and nuclear factor kappa-B are among the molecular pathways addressed by natural products. Plant substances like spices, vegetables, fruits, and medicinal plants have anticancer activities. The current state of knowledge on tumor angiogenesis' molecular targets and the active compounds from natural sources that have been shown to inhibit cancer angiogenesis.