Affiliation:
1. University of Verona, Italy
Abstract
The Intravenous Glucose Tolerance Test is an experimental procedure used to study the glucose-insulin endocrine regulatory system. An open problem is to construct a model representing simultaneously the entire regulative mechanism. In the past three decades, several models have appeared, but they have not escaped criticisms and drawbacks. In this paper, the authors apply the Metabolic P systems theory for developing new physiologically based models of the glucose-insulin system, which can be applied to the IVGTT. Ten data-sets obtained from literature were considered and an MP model was found for each, which fits the data and explains the regulations of the dynamics. Finally, each model is analysed to define a common pattern which explains, in general, the action of the glucose-insulin control system.
Reference29 articles.
1. Assessment of Insulin Sensitivityin Vivo*
2. Quantitative estimation of insulin sensitivity.;R.Bergman;American Journal of Physiology. Endocrinology and Metabolism,1979
3. A critical review of mathematical models and data used in diabetology.;A.Boutayeb;Biomedical Engineering Online,2006
4. Data analysis pipeline from laboratory to MP models