Evaluation of Gastro-Protective Activity of Ethanolic Extract of Roots of Vernonia Cinerea Less

Abstract

Background: Vernonia cinerea Less is a little shrub that belongs to the Asteraceae family and is found all throughout India. It grows to a height of 0.5 to 3 feet and has purple or pink flowers that bloom during the rainy season. Vernonia cinerea root has been reported to be useful against stomach acidity. Aim: To evaluate gastro-protective activity of ethanolic extract of roots of vernonia cinerea less. Method: The gastro-protective activity of ethanolic fraction of root of Vernonia cinerea less plant was tested by using screening technique of anti-ulcer activity. Results and Conclusion: Administration of ethanolic extract of Vernonia cinerea less shows significant Anti-ulcer activity in a dose dependent manner (100mg/kg and 200mg/kg), when compared to control which is evident by decrease inulcer index. When compared to the control, the ethanolic extract of Vernonia cinerea roots exhibits less substantial anti-ulcer action in a dose-dependent manner, as evidenced by a drop in ulcer index. The ulcer index of Vernonia cinerea roots ethanolic extract is 3.16 0.600 at 100 mg/kg and 1.91 0.396 at 200 mg/kg. In comparison, the standard (Lansoprozole) mean ulcer index is 1.83 0.459.This result suggests that ethanolic extract of root of Vernonia cinerea less plant possess gastro protective(anti-ulcer) activity..