Investigation of microbial coinfection in 453 septic COVID-19 patients admitted to hospital; a retrospective study

Author:

Khavandegar Armin1ORCID,Siami Zeinab23ORCID,Goudarzi Sogand4,Rasooli Aziz5,Ettehad Yeganeh6

Affiliation:

1. Sina Trauma & Surgery Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

2. Infectious Disease Department, Alborz University of Medical Sciences, Karaj, Iran

3. Department of Infectious Diseases & Tropical Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran

4. Department of Anesthesiology & Perioperative Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA

5. Department of Emergency Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

6. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran

Abstract

Aim: We evaluated the rate of COVID-19 microbial coinfection in an Iranian population. Methods: In this single-center, retrospective observational study, we evaluated 453 septic COVID-19 patients for possible coinfection in an Iranian hospital. Results: Overall, 211 (46.57%) cases died due to COVID-19 complications. Positive respiratory secretion and blood cultures were reported in 99 (21.9%) and 19 (4.2%) cases. Klebsiella species were the most commonly isolated microorganisms in respiratory (n = 50, 50.5%) and blood (n = 10, 52.6%) specimens. After adjustment for underlying disorders, positive respiratory microbial cultures significantly increase the odds of developing death, intubation, and ICU admission and negatively impact healthy discharge (P < 0.05). Conclusion: Coinfections with bacteria and fungi independently contribute to poor outcomes in septic COVID-19 patients.

Publisher

Future Science Ltd

Subject

Biotechnology

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