Prognostic and clinicopathological significance of FOXD1 in various cancers: a meta and bioinformation analysis-Reference-Cited by-同舟云学术

Prognostic and clinicopathological significance of FOXD1 in various cancers: a meta and bioinformation analysis

Published:2023-09-07 Issue: Volume: Page:
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Liu Xiaohan¹²^ORCID,Min Shengyun³,Zhang Qin¹²^ORCID,Liu Yan¹²,Zou Zhenhong¹,Wang Nanye⁴,Zhou Bin⁵

Affiliation:

1. Department of general surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, P.R. China

2. Nanchang University, Nanchang, Jiangxi, People's Republic of China

3. Department of general surgery, Changzheng Hospital, Nanchang, Jiangxi, 330100, P.R. China

4. Department of ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, P.R. China

5. Department of orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China

Abstract

Aim: To examine both predictive and clinicopathological importance underlying FOXD1 in malignant tumors, our study adopts meta-analysis. Methods: We searched from PubMed, Embase, WOS, Wanfang and CNKI. Stata SE15.1 was used to calculate the risk ratio (HR) as well as relative risk (RR) with 95% of overall confidence intervals (CIs) to assess FOXD1 and overall survival rate (OS), disease-free survival rate ( FOXD1) as well as clinicopathological parameters. Results: 3808 individuals throughout 17 trials showed high FOXD1 expression was linked to disadvantaged OS (p < 0.001) and disease-free survival (p < 0.001) and higher TNM stage (p < 0.001). Conclusion: Elevated FOXD1 had worse predictions and clinicopathological parameters in most cancers. The GEPIA database findings also support our results.

Funder

Jiangxi Province Department of Education

The Youth Foundation project of the Jiangxi provincial science and Technology Department

Young Scientists Fund

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.2144/fsoa-2023-0085

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