Insights on monkeypox disease and its recent outbreak with evidence of nonsynonymous missense mutation

Author:

Elhusseiny Shaza M1ORCID,Bebawy Abraam S2ORCID,Saad Bishoy T3,Aboshanab Khaled M4ORCID

Affiliation:

1. Department of Microbiology & Immunology, Faculty of Pharmacy, Ahram Canadian University (ACU), 4th Industrial Area, 6th of October City, Cairo, 12566, Egypt

2. Department of Genomics, HITS Solutions Co., Cairo, 11765, Egypt

3. Department of Bioinformatics, HITS Solutions Co., Cairo, 11765, Egypt

4. Department of Microbiology & Immunology, Faculty of Pharmacy, Ain Shams University, Organization of African Unity St., Cairo, Abbassia, 11566, Egypt

Abstract

The 2022 monkeypox outbreak has created a new global health threat and pandemic. Monkeypox virus is a descendant of the genus Orthopoxvirus, producing a febrile skin rash disease in humans. Monkeypox is zoonotic transmitted and transmitted from human to human in several ways. Even though this disease is self-limited, it creates important community health worries due to its inconvenience and widespread complications. Herein, we discussed the up-to-date current situation of monkeypox regarding its epidemiology, clinical manifestations, current in-use therapeutics, necessary protective measures, and response to potential occurrences considering the recent pandemic. Also, in this review, a comparative genomic analysis of the recent circulating strains that have been recovered from various countries including, Egypt, USA, Spain, Japan and South Africa has been investigated.

Publisher

Future Science Ltd

Subject

Biotechnology

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