MULMINATM REVERSES MEMORY IMPAIRMENT INDUCED BY GABAPENTIN IN PTZ EPILEPTIC MOUSE MODEL AND EXHIBITS SYNERGISTIC ANTIEPILEPTIC ACTIVITY

Abstract

Epilepsy is a neurological condition that causes unprovoked, recurrent seizures and memory impairment is a common side effect of epileptic treatment. The present study was conceptualized to evaluate the protective effect of the nootropic herbal drink MulminaTM against memory impairment induced by Gabapentin in a pentylenetetrazole-induced epileptic mouse model. The antiepileptic and memory impairment activity were found to be significantly (p<0.05) higher in the gabapentin group, whereas the combination of gabapentin + MulminaTM significantly (p<0.05) increased antiepileptic and decreased the memory impairment activity. Furthermore, Mulmina, alone exhibited synergistic antiepileptic and memory enhancement activity. Thus, combining herbal drugs/nootropics with anti-epileptic drugs provides synergistic activity while lowering the dose of synthetic drugs, which may cause more adverse effects in the human body. The results of this study show that gabapentin has memory impairment potential and that it can be corrected by co-administration of MulminaTM. However, future research is warranted to assess the underlying molecular mechanism of memory enhancing activity of MulminaTM against gabapentin induced memory impairment.