Investigating the Theoretical Basis for In Vitro–In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science
Link
https://link.springer.com/content/pdf/10.1208/s12248-020-00501-9.pdf
Reference29 articles.
1. Page KM. Validation of early human dose prediction: a key metric for compound progression in drug discovery. Mol Pharm. 2015;13:609–20.
2. Krauss M, Hofmann U, Schafmayer C, Igel S, Schlender J, Mueller C, et al. Translational learning from clinical studies predicts drug pharmacokinetics across patient populations. NPJ Syst Biol Appl. 2017;3:11.
3. Rané A, Wilkinson GR, Shand DG. Prediction of hepatic clearance ratio from in vitro measurement of intrinsic clearance. J Pharmacol Exp Ther. 1977;200:420–4.
4. Houston JB. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochem Pharmacol. 1994;47:1469–79.
5. Houston JB. Prediction of hepatic clearance from microsomes, hepatocyte and liver slices. Drug Metab Rev. 1997;29:891–922.
Cited by 21 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science.;Xenobiotica;2023-12-14
2. 2021年度日本臨床薬理学会海外研修員報告: 研修完了報告書;Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics;2023-07-31
3. Drug Design and Success of Prospective Mouse In Vitro–In Vivo Extrapolation (IVIVE) for Predictions of Plasma Clearance (CLp) from Hepatocyte Intrinsic Clearance (CLint);Molecular Pharmaceutics;2023-05-26
4. Assumptions Underlying Hepatic Clearance Models: Recognizing the Influence of Saturable Protein Binding on Driving Force Concentration and Discrimination Between Models of Hepatic Clearance;Drug Metabolism and Disposition;2023-05-15
5. In vitro metabolism of the new antifungal dapaconazole using liver microsomes;Drug Metabolism and Pharmacokinetics;2022-12
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"全球学者库"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前全球学者库共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2023 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3