Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole-Genome Analysis of 7,840 Patients

Author:

Zhou Yi-Hui12ORCID,Gallins Paul J.1,Pace Rhonda G.3,Dang Hong3,Aksit Melis A.4,Blue Elizabeth E.56,Buckingham Kati J.7,Collaco Joseph M.8,Faino Anna V.9,Gordon William W.7,Hetrick Kurt N.10,Ling Hua10,Liu Weifang11,Onchiri Frankline M.9,Pagel Kymberleigh12,Pugh Elizabeth W.10,Raraigh Karen S.4,Rosenfeld Margaret1314,Sun Quan11,Wen Jia15,Li Yun111516,Corvol Harriet1718,Strug Lisa J.1920212223,Bamshad Michael J.5724,Blackman Scott M.425ORCID,Cutting Garry R.4,Gibson Ronald L.1314,O’Neal Wanda K.3,Wright Fred A.1226,Knowles Michael R.3

Affiliation:

1. Bioinformatics Research Center,

2. Department of Biological Sciences, and

3. Marsico Lung Institute/UNC CF Research Center, School of Medicine,

4. McKusick-Nathans Department of Genetic Medicine,

5. Brotman Baty Institute for Precision Medicine, Seattle, Washington;

6. Division of Medical Genetics, Department of Medicine,

7. Division of Genetic Medicine, Department of Pediatrics,

8. Eudowood Division of Pediatric Respiratory Sciences,

9. Children’s Core for Biostatistics, Epidemiology and Analytics in Research and

10. Department of Genetic Medicine, Center for Inherited Disease Research, and

11. Department of Biostatistics,

12. The Institute for Computational Medicine, The Johns Hopkins University, Baltimore, Maryland;

13. Department of Pediatrics, and

14. Center for Clinical and Translational Research, Seattle Children’s Research Institute, Seattle, Washington;

15. Department of Genetics, and

16. Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

17. Pediatric Pulmonary Department, Assistance Publique-Hôpitaux de Paris, Hôpital Trousseau, Paris, France;

18. Centre de Recherche Saint Antoine, Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Paris, France;

19. Division of Biostatistics, Dalla Lana School of Public Health,

20. Department of Statistical Sciences, and

21. Department of Computer Science, University of Toronto, Toronto, Ontario, Canada; and

22. Program in Genetics and Genome Biology and

23. The Center for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada

24. Department of Genome Sciences, University of Washington, Seattle, Washington;

25. Division of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland;

26. Department of Statistics, North Carolina State University, Raleigh, North Carolina;

Funder

Cystic Fibrosis Foundation

Canadian Institutes of Health Research

Cystic Fibrosis Canada

Genome Canada

Government of Ontario

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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