Treatment Trials in Young Patients with Chronic Obstructive Pulmonary Disease and Pre–Chronic Obstructive Pulmonary Disease Patients: Time to Move Forward

Author:

Martinez Fernando J.1ORCID,Agusti Alvar2345,Celli Bartolome R.6,Han MeiLan K.7,Allinson James P.8,Bhatt Surya P.9,Calverley Peter10,Chotirmall Sanjay H.11ORCID,Chowdhury Badrul12,Darken Patrick13,Da Silva Carla A.14,Donaldson Gavin8,Dorinsky Paul13,Dransfield Mark9,Faner Rosa15,Halpin David M.16,Jones Paul17,Krishnan Jerry A.18ORCID,Locantore Nicholas19,Martinez Fernando D.20,Mullerova Hana21,Price David2223ORCID,Rabe Klaus F.2425,Reisner Colin26,Singh Dave27,Vestbo Jørgen28ORCID,Vogelmeier Claus F.29,Wise Robert A.30ORCID,Tal-Singer Ruth31,Wedzicha Jadwiga A.8

Affiliation:

1. Weill Cornell Medicine, NewYork-Presbyterian Hospital, New York, New York;

2. Catedra Salut Respiratoria and

3. Institut Respiratorio, Hospital Clinic, Barcelona, Spain;

4. Institut d’investigacions biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;

5. Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain;

6. Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts;

7. University of Michigan Health System, Ann Arbor, Michigan;

8. National Heart and Lung Institute, Imperial College, London, United Kingdom;

9. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama;

10. Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom;

11. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore;

12. Savara Pharmaceuticals, Inc., Austin, Texas;

13. AstraZeneca, Gaithersburg, Maryland;

14. Clinical Development, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden;

15. Department of Biomedical Sciences, University of Barcelona, Barcelona, Spain;

16. Royal Devon and Exeter Hospital, Exeter, United Kingdom;

17. St. George’s University of London, London, United Kingdom;

18. University of Illinois, Chicago, Illinois;

19. Nimirga LLC, Durham, North Carolina;

20. University of Arizona, Tucson, Arizona;

21. AstraZeneca, Cambridge, United Kingdom;

22. Observational and Pragmatic Research Institute, Singapore;

23. Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom;

24. LungenClinic Grosshansdorf, Member of the German Center for Lung Research, Grosshansdorf, Germany;

25. Department of Medicine, Christian Albrechts University Kiel, Member of the German Center for Lung Research Kiel, Germany;

26. DevPro Biopharma, Basking Ridge, New Jersey;

27. Medicines Evaluation Unit and

28. Manchester University NHS Trust, Manchester, United Kingdom;

29. Department of Medicine, Pulmonary and Critical Care Medicine, University of Marburg, Member of the German Center for Lung Research, Marburg, Germany;

30. Johns Hopkins Medicine, Baltimore, Maryland; and

31. COPD Foundation, Washington, DC

Funder

NIH/NHLBI

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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