Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis

Author:

Gonçales Relber A.12,Bastos Helder Novais345,Duarte-Oliveira Cláudio12,Antunes Daniela12,Sokhatska Oksana6,Jacob Maria5,Rolo Rui7,Campos Cláudia F.12,Sasaki Sergio D.128,Donato Alessia910,Mapelli Sarah N.910,Costa Sandra12,Moura Conceição Souto11,Delgado Luís612,Morais António5,Torrado Egídio12,van de Veerdonk Frank L.13ORCID,Weichhart Thomas14,Lambris John D.15,Silvestre Ricardo12,Garlanda Cecilia910,Mantovani Alberto91016,Cunha Cristina12ORCID,Carvalho Agostinho12ORCID

Affiliation:

1. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal;

2. ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal;

3. i3S - Instituto de Investigação e Inovação em Saúde,

4. IBMC - Instituto de Biologia Molecular e Celular,

5. Department of Pneumology and

6. Basic and Clinical Immunology, Department of Pathology, Faculty of Medicine, and

7. Department of Pneumology, Hospital de Braga, Braga, Portugal;

8. Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, São Bernardo do Campo, São Paulo, Brazil;

9. IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy;

10. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy;

11. Department of Pathology, Centro Hospitalar Universitário de São João, Porto, Portugal;

12. Center for Health Technology and Services Research (CINTESIS@RISE), Faculty of Medicine, University of Porto, Porto, Portugal;

13. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands;

14. Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria;

15. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and

16. William Harvey Research Institute, Queen Mary University, London, United Kingdom

Funder

“la Caixa” Foundation

H2020 Societal Challenges

European Regional Development Fund

Fundação para a Ciência e a Tecnologia

Associazione Italiana Ricerca sul Cancro

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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