Episodic Aspiration with Oral Commensals Induces a MyD88-dependent, Pulmonary T-Helper Cell Type 17 Response that Mitigates Susceptibility to Streptococcus pneumoniae

Author:

Wu Benjamin G.123ORCID,Sulaiman Imran12,Tsay Jun-Chieh J.123,Perez Luisanny12,Franca Brendan12,Li Yonghua12,Wang Jing14,Gonzalez Amber N.12,El-Ashmawy Mariam2,Carpenito Joseph12,Olsen Evan12,Sauthoff Maya12,Yie Kevin12,Liu Xiuxiu5,Shen Nan6,Clemente Jose C.6,Kapoor Bianca2,Zangari Tonia7,Mezzano Valeria89,Loomis Cynthia810,Weiden Michael D.12,Koralov Sergei B.10,D’Armiento Jeanine11,Ahuja Sunil K.12,Wu Xue-Ru1013,Weiser Jeffrey N.7,Segal Leopoldo N.12

Affiliation:

1. Division of Pulmonary, Critical Care and Sleep Medicine

2. Department of Medicine

3. Division of Pulmonary and Critical Care, New York Harbor Veterans Affairs, New York, New York

4. Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

5. Division of Pediatrics, Longhua Hospital, Shanghai University of Chinese Medicine, Shanghai, China

6. Department of Genetics and Genomic Sciences and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York

7. Department of Microbiology

8. Division of Cardiology, Department of Medicine and

9. Experimental Pathology Research Laboratory, Division of Advanced Research Technologies, and

10. Department of Pathology, NYU Langone Health, New York, New York

11. Department of Anesthesiology, School of Medicine, Columbia University, New York, New York; and

12. University of Texas Health Science Center, San Antonio, Texas

13. Department of Urology, School of Medicine, New York University, New York, New York

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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