Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose-associated 90-Day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE III)

Author:

Shehabi Yahya12,Serpa Neto Ary345,Bellomo Rinaldo356,Howe Belinda D.3,Arabi Yaseen M.7ORCID,Bailey Michael3,Bass Frances E.89,Bin Kadiman Suhaini10,McArthur Colin J.11,Reade Michael C.1213,Seppelt Ian M.1415,Takala Jukka16,Wise Matt P.17,Webb Steve A.318,Mashonganyika C.,McKee H.,Tonks A.,Donnelly A.,Hemmings N.,O’Kane S.,Blakemore A.,Butler M.,Cowdrey K.,Dalton J.,Gilder E.,Long S.,McCarthy L.,McGuinness S.,Parke R.,Chen Y.,McArthur C.,McConnochie R.,Newby L.,Bellomo R.,Eastwood G.,Peck L.,Young H.,Boschert C.,Edington J.,Fletcher J.,Smith J.,Nand K.,Raza A.,Sara T.,Bennett-Britton J.,Bewley J.,Bodenham V.,Cole L.,Driver K.,Grimmer L.,Howie L.,Searles C.,Sweet K.,Webster D.,van Berkel A.,Connor H.,Dennett J.,van Der Graaff M.,Henderson S.,Mehrtens J.,Miller K.,Minto E.,Morris A.,Noble S.,Parker K.,Bulfin L.,Hart N.,Shepherd K.,Vij S.,Dickson S.,Elloway E.,Ferguson C.,Jackson R.,MacNaughton P.,Marner M.,Squire R.,Waddy S.,Wafer P.,Welbourne J.,Ashcroft P.,Chambler D.,Dukes S.,Harris A.,Horton S.,Sharpe S.,Williams P.,Williams S.,Bailey M.,Blazquez E.,France D.,Hutchison R.,O’Connor A.,Comadira G.,Gough M.,Tallott M.,Bastick M.,Cameron R.,Donovan S.,Ellis K.,Gaur A.,Gregory R.,Naumoff J.,Turner E.,White M.,Au K. F. J.,Fratzia J.,Treloar S.,Lim C. H.,Maseeda Y.,Tan A. P.,Tang C. L.,Yong C. Y.,Akaltan M.,Berger S.,Blaser D.,Fazlija L.,Jong M. L.,Lensch M.,Ludwig R.,Merz T.,Nettelbeck K.,Roth M.,Schafer M.,Takala J.,Wehr A.,Zacharias D.,Amran R.,Ashraf H. N.,Azmi N.,Basri N.,Burhanuddin H.,Hadinata Y.,Hamdan A.,Kadiman S.,Rashid A. I. Y. M.,Sabran I. N.,Sulaiman S.,Zabidi I. N.,Al-Dawood A.,Aljuaid M.,Anizi H. Al,Saeedi A. Al,Arabi Y.,Dbsawy M.,Deeb A.,Hegazy M.,Magdi I.,Clarey E.,Corcoran E.,Finney C.,Harris C.,Hopkins P.,Noble H.,Smith J.,Thompson L.,Williams T.,Dumlao L. A.,Bassam R.,Hassan M. A.,Naseem N.,Al-Kurdi M. H.,Al-Harthy A. M.,Bernard S.,Sebafundi L.,Serban C.,Lim S. K.,Mazidah N.,Saidin N.,Sjamsuddin N.,Tan I. T. A.,Zabidi N.,Brain M.,Mineall S.,Kanhere M.,Soar N.,Kadir N. Abd,Abdullah N. H.,Awang R.,Emperan Z.,Husin N. S.,Ismail N. I.,Ismail S. Z.,Khadzali F. N. A. Mohd,Norddin M. F.,Aguila J.,Bold C.,Clatworthy B.,Dias A.,Hogan C.,Kazemi A.,Lai V.,Song R.,Williams A.,Bhatia D.,Bulfin L.,Elliot S.,Galt P.,Lavrans K.,Ritchie P.,Wang A.,Gresham R.,Lowrey J.,Masters K.,Palejs P.,Seppelt I.,Symonds F.,Weisbrodt L.,Whitehead C.,Babio-Galan M.,Calder V.,Clement I.,Harrison A.,McCullagh I.,Scott C.,Thompson L.,Bevan R.,Caniba S.,Hacking D.,Maher L.,Azzolini M. L.,Beccaria P.,Colombo S.,Landoni G.,Leggieri C.,Luca C.,Mamo D.,Moizo E.,Monti G.,Mucci M.,Zangrillo A.,Albania M.,Arora S.,Shi Y.,Abudayah A.,Almekhlafi G.,Al Amodi E.,Al Samarrai S.,Badawi M.,Caba R. Cubio,Elffaki O.,Mandourah Y.,Valerio J.,Joyce C.,Meyer J.,Saylor E.,Venkatesh B.,Venz E.,Walsham J.,Wetzig K.,Clarey E.,Harris C.,Hopkins P.,Noble H.,Thompson L.,Williams T.,Khoo T. M.,Liew J. E. S.,Sakthi A. N.,Zulkurnain A.,Bamford A.,Bergin C.,Carrera R.,Cooper L.,Despy L.,Ellis K.,Harkett S.,Mee L.,Reeves E.,Snelson C.,Spruce E.,Cooper G.,Hodgson R.,Pearson D.,Rosbergen M.,Ali M. N.,Bahar N. I.,Ismail A.,Ismail W. N. W.,Samat N. M.,Piah N. S. M.,Rahman R. Abd,Duroux M.,Ratcliffe M.,Warhurst T.,Buehner U.,Williams E.,Jacques N.,Keating L.,Macgill S.,Tamang K. L.,Tolan N.,Walden A.,Bower R.,Cranshaw J.,Molloy K.,Pitts S.,Butler J.,Dunlop R.,Fourie C.,Jarrett P.,Lassig-Smith M.,Livermore A.,O’Donoghue S.,Reade M.,Starr T.,Stuart J.,Campbell L.,Phillips M.,Stephens D.,Thomas J.,Cooper D.,McAllister R.,Andrew G.,Barclay L.,Dawson H.,Griffith D. M.,Hope D.,Wojcik G.,McCulloch C.,Paterson R.,Ascough L.,Paisley C.,Patrick-Heselton J.,Shaw D.,Waugh V.,Williams K.,Welters I.,Barge D.,Jordan A.,MacIsaac C.,Rechnitzer T.,Bass F.,Gatward J.,Hammond N.,Janin P.,O’Connor A.,Stedman W.,Yarad E.,Razak N. A.,Dzulkipli N.,Jong S. L.,Asen K.,Voon W. L.,Liew S.,Ball J.,Barnes V.,Dalton C.,Farnell-Ward S.,Farrah H.,Maher K.,Mellinghoff J.,Ryan C.,Shirley P.,Conlon L.,Glover A.,Martin-Loeches I.,O’Toole E.,Ewan J.,Ferrier J.,Litton E.,Webb S. A.,Berry W.,Blanco Alonso U.,Bociek A.,Campos S.,Jawara S.,Hanks F.,Kelly A.,Lei K.,McKenzie C.,Ostermann M.,Wan R.,Al-Soufi S.,Leow S.,McCann K.,Reynolds C.,Brickell K.,Fahey C.,Hays L.,Hyde N.,Nichol A.,Ryan D.,Brailsford J.,Buckley A.,Forbes L.,Maguire T.,Moore J.,Murray L.,Ghosh A.,Park M.,Said S.,Smith J.,Visser A.,Abidin H. Z.,Ali S.,Hassan M. H.,Omar S. C.,Shukeri W. F. W.,Brealey D.,Bercades G.,Blackburn E.,Macallum N.,Macklin A.,Ryu J. H.,Tam K.,Smyth D.,Arif A.,Bassford C.,Morgan C.,Swann C.,Ward G.,Wild L.,Bone A.,Elderkin T.,Green D.,Sach D.,Salerno T.,Simpson N.,Brohi F.,Clark M.,Williams L.,Brooks J.,Cocks E.,Cole J.,Curtin J.,Davies R.,Hill H.,Morgan M.,Palmer N.,Whitton C.,Wise M.,Baskaran P.,Hasan M. S.,Tham L. Y.,Sol Cruz R.,Dinsdale D.,Edney S.,Firkin C.,FitzJohn F.,Hill G.,Hunt A.,Hurford S.,Jones G.,Judd H.,Latimer-Bell C.,Lawrence C.,Lesona E.,Navarra L.,Robertson Y.,Smellie H.,Vucago A. M.,Young P.,Dawson H.,Griffith D. M.,Paterson R.,Clark P.,Kong J.,Ho J.,Nayyar V.,Skelly C.

Affiliation:

1. Monash Health School of Clinical Sciences and

2. School of Clinical Medicine and

3. Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia;

4. Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil;

5. Department of Critical Care, Data Analytics Research and Evaluation Centre, Faculty of Medicine, University of Melbourne, Melbourne, Victoria, Australia;

6. Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia;

7. College of Medicine, King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia;

8. Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia;

9. Malcolm Fisher Department of Intensive Care, Royal North Shore Hospital, St. Leonards, New South Wales, Australia;

10. Department of Anesthesiology and Intensive Care, IJN-UTM Cardiovascular Engineering Center, National Heart Institute, Kuala Lumpur, Malaysia;

11. Department of Critical Care Medicine, Auckland City Hospital, University of Auckland, Auckland, New Zealand;

12. Faculty of Medicine, University of Queensland, Royal Brisbane and Women’s Hospital, Brisbane, Australia;

13. Joint Health Command, Australian Defence Force, Canberra, Australian Capital Territory, Australia;

14. Sydney Medical School–Nepean, University of Sydney, Sydney, New South Wales, Australia;

15. Department of Clinical Medicine, Macquarie University, Sydney, New South Wales, Australia;

16. Department of Intensive Care Medicine, Bern University Hospital, University of Bern, Bern, Switzerland;

17. Adult Critical Care, University Hospital of Wales, Cardiff, United Kingdom; and

18. Intensive Care Unit, Royal Perth Hospital, Perth, Western Australia, Australia

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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