A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated <i>Streptococcus pneumoniae</i> Strains Using Human Infection Challenge-Reference-Cited by-同舟云学术

A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge

Published:2023-10-15 Issue:8 Volume:208 Page:868-878
ISSN:1073-449X
Container-title:American Journal of Respiratory and Critical Care Medicine
language:en
Short-container-title:Am J Respir Crit Care Med

Author:

Hill Helen¹,Mitsi Elena¹²^ORCID,Nikolaou Elissavet¹,Blizard Annie¹,Pojar Sherin¹,Howard Ashleigh¹,Hyder-Wright Angela¹³,Devin Jack¹,Reiné Jesus¹²,Robinson Ryan¹³^ORCID,Solórzano Carla¹²,Jochems Simon P.¹^ORCID,Kenny-Nyazika Tinashe¹,Ramos-Sevillano Elisa⁴^ORCID,Weight Caroline M.⁵,Myerscough Chris¹,McLenaghan Daniella¹,Morton Ben¹^ORCID,Gibbons Emily¹,Farrar Madlen¹,Randles Victoria¹³,Burhan Hassan³,Chen Tao¹,Shandling Adam D.⁶,Campo Joe J.⁶,Heyderman Robert S.⁵^ORCID,Gordon Stephen B.¹⁷,Brown Jeremy S.⁴,Collins Andrea M.¹³,Ferreira Daniela M.¹²

Affiliation:

1. Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;

2. Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom;

3. Liverpool University Hospitals National Health Service Foundation Trust, Liverpool, United Kingdom;

4. UCL Respiratory, Division of Medicine, University College London, London, United Kingdom;

5. Division of Infection and Immunity, University College London, London, United Kingdom;

6. Antigen Discovery Inc, Irvine, California; and

7. Malawi Liverpool Wellcome-Trust Programme, Blantyre, Malawi

Funder

Bill and Melinda Gates Foundation

Medical Research Council

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

Link

https://www.atsjournals.org/doi/pdf/10.1164/rccm.202302-0222OC

Reference39 articles.

1. Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000–15

2. Pneumococcal whole-cell and protein-based vaccines: changing the paradigm

3. The current burden of pneumococcal disease in England and Wales

4. Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD

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