A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge

Author:

Hill Helen1,Mitsi Elena12ORCID,Nikolaou Elissavet1,Blizard Annie1,Pojar Sherin1,Howard Ashleigh1,Hyder-Wright Angela13,Devin Jack1,Reiné Jesus12,Robinson Ryan13ORCID,Solórzano Carla12,Jochems Simon P.1ORCID,Kenny-Nyazika Tinashe1,Ramos-Sevillano Elisa4ORCID,Weight Caroline M.5,Myerscough Chris1,McLenaghan Daniella1,Morton Ben1ORCID,Gibbons Emily1,Farrar Madlen1,Randles Victoria13,Burhan Hassan3,Chen Tao1,Shandling Adam D.6,Campo Joe J.6,Heyderman Robert S.5ORCID,Gordon Stephen B.17,Brown Jeremy S.4,Collins Andrea M.13,Ferreira Daniela M.12

Affiliation:

1. Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;

2. Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom;

3. Liverpool University Hospitals National Health Service Foundation Trust, Liverpool, United Kingdom;

4. UCL Respiratory, Division of Medicine, University College London, London, United Kingdom;

5. Division of Infection and Immunity, University College London, London, United Kingdom;

6. Antigen Discovery Inc, Irvine, California; and

7. Malawi Liverpool Wellcome-Trust Programme, Blantyre, Malawi

Funder

Bill and Melinda Gates Foundation

Medical Research Council

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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