Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials

Author:

Zinter Matt S.1ORCID,Markovic Daniela2,Asaro Lisa A.3,Nadkarni Vinay M.4,McQuillen Patrick S.56,Sinha Pratik7,Matthay Michael A.8,Jeschke Marc G.910,Agus Michael S. D.1112,Sapru Anil13ORCID,Agus Michael,Coughlin-Wells Kerry,Hughes Kyle,French Jaclyn,Fitzgerald Meghan,Srinivasan Vijay,Sisko Martha,Chima Ranjit S.,Howard Kelli,Jones Rhonda,Thomas Neal J,Spear Debbie,Li Simon,Pinto Alan,Eldridge Peter,Newth Christopher,Kwok Jeni,Hassinger Amanda B,Qiao Haiping,Bysani Kris,Monjure Tracey,Vincent Faustino Edward,Tala Joana,Kandil Sarah A,Quinn Tyler,Hirshberg Eliotte,Lilley Jennifer,Wintergerst Kupper,Sullivan Janice E,Lee Kristen,Schwarz Adam,Flores Cathy,Vargas-Shiraishi Ofelia,Sorce Lauren,Marsillio Lauren,Shukla Avani,Cvijanovich Natalie,Flori Heidi,Brumfield Becky,Stone Cheryl,Dahmer Mary,Jayachandran Chaandini,Federman Myke,Wong Kayley,Vangala Sitaram S,Pellegrini Matteo,Balliu Brunilda,Gala Kinisha P,Kirkpatrick Theresa,Deshmukh Tanaya,Mareboina Manvita,Do Nguyen,Ashtari Neda,Ratiu Anna,Nett Sholeen,Singleton Marcy,Jarvis Dean,McNally Mary,Martini Karlyn,Pinto Neethi,Chong Grace,Rodgers Chiara,Viteri Shirley,John Ramany,Mulholland Teresa,Pellicciotti Gwen,Sapru Anil,McQuillen Patrick,Zinter Matt,Goel Shrey,Alkhouli Mustafa,McKenzie Anne,Villarreal-Chico Denise

Affiliation:

1. Divisions of Critical Care Medicine and Allergy, Immunology, and Bone Marrow Transplant,

2. Division of General Internal Medicine and Health Sciences Research, Department of Medicine, and

3. Department of Cardiology and

4. Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

5. Division of Critical Care Medicine, Department of Pediatrics,

6. Department of Neurology, and

7. Division of Clinical and Translational Research, Department of Anesthesia, Washington University, Saint Louis, Missouri;

8. Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California;

9. Division of Plastic Surgery, Department of Surgery, and

10. Department of Immunology, University of Toronto, Toronto, Ontario, Canada; and

11. Division of Medical Critical Care, Department of Pediatrics, Boston Children’s Hospital, Boston, Massachusetts;

12. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts

13. Division of Critical Care Medicine, Department of Pediatrics, University of California, Los Angeles, Los Angeles, California;

Funder

National Institute of General Medical Sciences

National Heart, Lung, and Blood Institute

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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