Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease

Author:

Opron Kristopher1,Begley Lesa A.1,Erb-Downward John R.1,Li Gen2,Alexis Neil E.3,Barjaktarevic Igor4,Barr R. Graham56,Bleecker Eugene R.7,Boucher Richard8,Bowler Russell P.9ORCID,Christenson Stephanie A.10,Comellas Alejandro P.111213ORCID,Criner Gerard14,Cooper Christopher B.4,Couper David15,Galban Craig J.11ORCID,Han MeiLan K.1,Hastie Annette16ORCID,Hatt Charles11,Hoffman Eric A.111213ORCID,Kaner Robert J.17,Kesimer Mehmet8,Krishnan Jerry A.18ORCID,LaFon David C.19ORCID,Martinez Fernando J.17,Ortega Victor E.16,Peters Stephen P.16,Paine Robert20,Putcha Nirupama21,Woodruff Prescott G.10,Huffnagle Gary B.122,Kozik Ariangela J.122ORCID,Curtis Jeffrey L.123ORCID,Huang Yvonne J.124ORCID,Alexis Neil E.,Anderson Wayne H.,Arjomandi Mehrdad,Barjaktarevic Igor,Barr R. Graham,Basta Patricia,Bateman Lori A.,Bellinger Christina,Bhatt Surya P.,Bleecker Eugene R.,Boucher Richard C.,Bowler Russell P.,Buhr Russell G.,Christenson Stephanie A.,Comellas Alejandro P.,Cooper Christopher B.,Couper David J.,Criner Gerard J.,Crystal Ronald G.,Curtis Jeffrey L.,Doerschuk Claire M.,Dransfield Mark T.,Drummond M. Bradley,Freeman Christine M.,Galban Craig,Gershner Katherine,Han MeiLan K.,Hansel Nadia N.,Hastie Annette T.,Hoffman Eric A.,Huang Yvonne J.,Kaner Robert J.,Kanner Richard E.,Kesimer Mehmet,Kleerup Eric C.,Krishnan Jerry A.,Labaki Wassim W.,LaVange Lisa M.,Lazarus Stephen C.,Martinez Fernando J.,McDonald Merry-Lynn,Meyers Deborah A.,Moore Wendy C.,Newell John D.,Oelsner Elizabeth C.,Ohar Jill,O’Neal Wanda K.,Ortega Victor E.,Paine Robert,Paulin Laura,Peters Stephen P.,Pirozzi Cheryl,Putcha Nirupama,Raman Sanjeev,Rennard Stephen I.,Tashkin Donald P.,Wells J. Michael,Wise Robert A.,Woodruff Prescott G.

Affiliation:

1. Department of Medicine, Division of Pulmonary and Critical Care Medicine,

2. Department of Biostatistics, School of Public Health,

3. Center for Environmental Medicine, Asthma, and Lung Biology, Division of Allergy and Immunology,

4. University of California, Los Angeles, Los Angeles, California;

5. Department of Medicine, Division of General Medicine and

6. Department of Epidemiology, Columbia University Medical Center, New York, New York;

7. University of Arizona, Tucson, Arizona;

8. Marsico Lung Institute/Cystic Fibrosis and Pulmonary Research Center, and

9. Department of Medicine, National Jewish Health, Denver, Colorado;

10. Department of Medicine, University of California, San Francisco, San Francisco, California;

11. Department of Radiology,

12. Department of Medicine, Division of Pulmonary and Critical Care Medicine, and

13. Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa;

14. Temple University, Philadelphia, Pennsylvania;

15. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

16. Wake Forest School of Medicine, Winston-Salem, North Carolina;

17. Weill Cornell, Division of Pulmonary and Critical Care Medicine, New York, New York;

18. Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Breathe Chicago Center, University of Illinois Chicago, Chicago, Illinois;

19. Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Alabama;

20. Division of Respiratory, Critical Care, Occupational Pulmonary Medicine, University of Utah, Salt Lake City, Utah;

21. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland; and

22. Department of Molecular, Cellular and Developmental Biology and

23. Medical Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan

24. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan;

Funder

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

Publisher

American Thoracic Society

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