Application of fibrin in drug technology: Achievements and perspectives

Abstract

In recent years, fibrin has been successfully used as a polymer drug delivery carrier. Passive properties of fibrin provide parenteral and local delivery of drug substances in controlled and prolonged manner and also tissue support, gluing and sealing. Fibrin also has hemostatic and proangiogenic effects. Discs, films, gels, beads and nanoparticles are among the most commonly proposed and used fibrin-based formulations. It is routinely obtained from fibrinogen and thrombin. Fibrin formulation methods are solution casting, dual syringe systems and emulsification. All fibrin formulations become gel after administration and water absorption. Biodegradation and biocompatibility are important advantages of fibrin, which make it possible to implant a formulation without the need to remove the carrier from the body after the drug is released. Fibrin-based drug delivery systems are proposed and applied in the treatment of wounds, infections and cancerous diseases.