Design of the neutron generator for the development of boron neutron capture therapy

Author:

Bezshyyko Oleg1ORCID,Golinka-Bezshyyko Larysa1ORCID

Affiliation:

1. Nuclear Physics Department, Faculty of Physics, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine

Abstract

In this article, we present the modern state of development of boron neutron capture therapy (BNCT) for cancer treatment using compact neutron generators. In the introduction we consider the main advantages and problems of the BNCT method, the main approaches and directions for building neutron sources, the development of chemical materials – boron-containing delivery agents and the control of irradiation of malignant tumours and healthy tissues. In the main part of the article we consider the main structures of neutron generators that can be effective for applying in BNCT. The development and building of a prototype of a compact neutron generator is also described.

Publisher

Index Copernicus

Subject

Health Informatics,Biochemistry, Genetics and Molecular Biology (miscellaneous),Medicine (miscellaneous),General Computer Science

Reference16 articles.

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2. INTERNATIONAL ATOMIC ENERGY AGENCY, Advances in Boron NeutronCapture Therapy, Non-serial Publications, IAEA, Vienna, 2023.

3. INTERNATIONAL ATOMIC ENERGY AGENCY, Current Status of NeutronCapture Therapy, TECDOC 1223, IAEA, Vienna, 2001.

4. Nedunchezhian K, Aswath N, Thiruppathy M, Thirugnanamurthy S. BoronNeutron Capture Therapy - A Literature Review. J Clin Diagn Res. 2016 Dec;10(12): ZE01-ZE04.

5. TAE Life Sciences [Internet] Developing targeted drugs for boron neutroncapture therapy to treat refractory cancers, 2021 [cited 2023 Dec 04].Available from: www.nature.com/biopharmdeal, www.taelifesciences.com.

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