Extraction and Clinical Application of Calendula officinalis L. Flowers Cream

Abstract

Abstract The results of the HPLC analysis indicated that marigold flowers extract contain nine different active compounds, including Vitexin 11.40%, Rutin 12.29%, Quercetin-3-3galactosid 12.64%, Luteolin-7-glucose9.27%, Quercetin-3-glucoside 7.38%, Quercitrin 9.83%, Myricetin 10%, Luteolin 10.72%, Apigenin 7.08% and kampferol 9.37 %. The results of a clinical study showed the effect of marigold flowers extract cream as an antioxidant which protected the skin in particular from oxidative damage after sunburn and reduced the symptoms of skin aging. This effect was evident in both concentrations 10% and 15% when compared with control. Control response rate, 10% of marigold flowers cream and 15% of flowers extract cream were reached to 76%, 85% and 92% within two weeks of treatment respectively. The Conclusion of this study showed the importance of marigold flowers extract as a source of bioactive compounds such as rutin and quercetin derivatives, vitexin, luteoline, apigenin and kampferol which act as an antioxidant to restore skin health and aging resistance. This study approved that marigold flowers extract characteristics can make it the main ingredients in the preparation of topical agents for the treatment of various skin desases.