Abstract
Abstract
Adequate vascularization is a critical determinant for the successful construction and clinical implementation of complex organotypic tissue models. Currently, low cell and vessel density and insufficient vascular maturation make vascularized organotypic tissue construction difficult, greatly limiting its use in tissue engineering and regenerative medicine. To address these limitations, recent studies have adopted pre-vascularized microtissue assembly for the rapid generation of functional tissue analogs with dense vascular networks and high cell density. In this article, we summarize the development of module assembly-based vascularized organotypic tissue construction and its application in tissue repair and regeneration, organ-scale tissue biomanufacturing, as well as advanced tissue modeling.
Funder
National Natural Science Foundation of China
111 Project
Tsinghua-Toyota Joint Research Fund
Beijing Natural Science Foundation
Beijing Nova Program
Tsinghua University Initiative Scientific Research Program
Natural Science Foundation of Chongqing Municipality
National Key Research and Development Program of China
Subject
Industrial and Manufacturing Engineering