mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory-Reference-Cited by-同舟云学术

mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory

Published:2023-11-28 Issue:49 Volume:120 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Sharma Vijendra¹,Oliveira Mauricio M.²,Sood Rapita³⁴,Khlaifia Abdessattar⁵⁶,Lou Danning³⁴^ORCID,Hooshmandi Mehdi⁷,Hung Tzu-Yu³⁴,Mahmood Niaz³⁴,Reeves Maya¹,Ho-Tieng David⁷,Cohen Noah³⁴,Cheng Po-chieh³⁴,Rahim Mir Munir A.¹,Prager-Khoutorsky Masha⁸,Kaufman Randal J.⁹^ORCID,Rosenblum Kobi¹⁰¹¹^ORCID,Lacaille Jean-Claude⁵^ORCID,Khoutorsky Arkady⁷¹²,Klann Eric²^ORCID,Sonenberg Nahum³⁴^ORCID

Affiliation:

1. Department of Biomedical Sciences, University of Windsor, Windsor, ON N9B3P4, Canada

2. Center for Neural Science, New York University, New York, NY 10003

3. Department of Biochemistry, McGill University, Montréal, QC H3G1Y6, Canada

4. Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC H3A1A3, Canada

5. Department of Neurosciences, Center for Interdisciplinary Research on Brain and Learning, Research Group on Neural Signaling and Circuitry, University of Montréal, Montréal, QC H3T1J4, Canada

6. Department of Psychology, University of Toronto Scarborough, Toronto, ON M1C1A4, Canada

7. Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montréal, QC H4A3J1, Canada

8. Department of Physiology, McGill University, Montreal, QC H3G1Y6, Canada

9. Degenerative Diseases Program Center for Genetic Disease and Aging Research Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA 92037

10. Sagol Department of Neurobiology, University of Haifa, Haifa 3498838, Israel

11. Center for Gene Manipulation in the Brain, University of Haifa, Haifa 3498838, Israel

12. Alan Edwards Centre for Research on Pain, McGill University, Montréal, QC H3A2B4, Canada

Abstract

Activation of neuronal protein synthesis upon learning is critical for the formation of long-term memory. Here, we report that learning in the contextual fear conditioning paradigm engenders a decrease in eIF2α (eukaryotic translation initiation factor 2) phosphorylation in astrocytes in the hippocampal CA1 region, which promotes protein synthesis. Genetic reduction of eIF2α phosphorylation in hippocampal astrocytes enhanced contextual and spatial memory and lowered the threshold for the induction of long-lasting plasticity by modulating synaptic transmission. Thus, learning-induced dephosphorylation of eIF2α in astrocytes bolsters hippocampal synaptic plasticity and consolidation of long-term memories.

Funder

Canadian HIV Trials Network, Canadian Institutes of Health Research

Foundation for the National Institutes of Health

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2308671120

Reference29 articles.

1. Translational Control of Long-Lasting Synaptic Plasticity and Memory

2. Altered protein synthesis is a trigger for long-term memory formation

3. eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory

4. Translational Control in the Brain in Health and Disease

5. eIF2α controls memory consolidation via excitatory and somatostatin neurons