Inhibition of EZH2 prevents fibrosis and restores normal angiogenesis in scleroderma-Reference-Cited by-同舟云学术

Inhibition of EZH2 prevents fibrosis and restores normal angiogenesis in scleroderma

Published:2019-02-12 Issue:9 Volume:116 Page:3695-3702
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Tsou Pei-Suen¹^ORCID,Campbell Phillip¹,Amin M. Asif¹,Coit Patrick¹,Miller Shaylynn¹,Fox David A.¹^ORCID,Khanna Dinesh¹²,Sawalha Amr H.¹³

Affiliation:

1. Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109;

2. Scleroderma Program, University of Michigan, Ann Arbor, MI 48109;

3. Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109

Abstract

Significance The key epigenetic regulator EZH2 plays a central role in fibrosis and abnormal angiogenesis in scleroderma. EZH2-target genes mediating profibrotic and antiangiogenic effects in scleroderma patients have been identified and characterized. Inhibiting EZH2 by repurposing already-existing EZH2 inhibitors currently being trialed in cancer might provide a therapeutic approach to scleroderma.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

Proceedings of the National Academy of Sciences

Link

https://pnas.org/doi/pdf/10.1073/pnas.1813006116

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