Infection-elicited microbiota promotes host adaptation to nutrient restriction

Author:

De Siqueira Mirian Krystel1,Andrade-Oliveira Vinicius23ORCID,Stacy Apollo23,Pedro Tôrres Guimarães João1,Wesley Alberca-Custodio Ricardo1ORCID,Castoldi Angela1,Marques Santos Jaqueline1,Davoli-Ferreira Marcela1,Menezes-Silva Luísa1,Miguel Turato Walter4,Han Seong-Ji23,Glatman Zaretsky Arielle23,Hand Timothy Wesley2,Olsen Saraiva Câmara Niels1,Russo Momtchilo1,Jancar Sonia1,Morais da Fonseca Denise1,Belkaid Yasmine23

Affiliation:

1. Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP 05508-000, Brazil

2. Metaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892

3. National Institute of Allergy and Infectious Diseases Microbiome Program, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892

4. Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP 05508-000, Brazil

Abstract

The microbiota performs multiple functions vital to host fitness, including defense against pathogens and adaptation to dietary changes. Yet, how environmental challenges shape microbiota resilience to nutrient fluctuation remains largely unexplored. Here, we show that transient gut infection can optimize host metabolism toward the usage of carbohydrates. Following acute infection and clearance of the pathogen, mice gained more weight as a result of white adipose tissue expansion. Concomitantly, previously infected mice exhibited enhanced carbohydrate (glucose) disposal and insulin sensitivity. This metabolic remodeling depended on alterations to the gut microbiota, with infection-elicited Betaproteobacteria being sufficient to enhance host carbohydrate metabolism. Further, infection-induced metabolic alteration protected mice against stunting in the context of limited nutrient availability. Together, these results propose that alterations to the microbiota imposed by acute infection may enhance host fitness and survival in the face of nutrient restriction, a phenomenon that may be adaptive in settings where both infection burden and food precarity are prevalent.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Fundação de Amparo à Pesquisa do Estado de São Paulo

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute of Dental and Craniofacial Research

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3