Helminth egg derivatives as proregenerative immunotherapies-Reference-Cited by-全球学者库

Helminth egg derivatives as proregenerative immunotherapies

Published:2023-02-13 Issue:8 Volume:120 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Maestas David R.¹^ORCID,Chung Liam¹²,Han Jin¹,Wang Xiaokun¹,Sommerfeld Sven D.¹,Kelly Sean H.¹^ORCID,Moore Erika¹³^ORCID,Nguyen Helen Hieu¹^ORCID,Mejías Joscelyn C.¹,Peña Alexis N.¹,Zhang Hong¹,Hooks Joshua S. T.¹,Chin Alexander F.¹,Andorko James I.¹²,Berlinicke Cynthia A.¹,Krishnan Kavita¹^ORCID,Choi Younghwan¹,Anderson Amy E.¹^ORCID,Mahatme Ronak¹^ORCID,Mejia Christopher¹,Eric Marie¹,Woo JiWon¹^ORCID,Ganguly Sudipto²⁴,Zack Donald J.⁵^ORCID,Zhao Liang²⁴^ORCID,Pearce Edward J.²⁴⁶,Housseau Franck²⁴^ORCID,Pardoll Drew M.²⁴,Elisseeff Jennifer H.¹²⁴

Affiliation:

1. Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287

2. Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, School of Medicine, Baltimore, MD 21287

3. Materials Science and Engineering, University of Florida, Gainesville, FL 32611

4. Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287

5. Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287

6. Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21287

Abstract

The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth Schistosoma mansoni soluble egg antigen (SEA) to stimulate production of interleukin (IL)-4 and other type 2-associated cytokines without negative infection-related sequelae. The regenerative SEA (rSEA) applied to a murine muscle injury induced accumulation of IL-4-expressing T helper cells, eosinophils, and regulatory T cells and decreased expression of IL-17A in gamma delta (γδ) T cells, resulting in improved repair and decreased fibrosis. Encapsulation and controlled release of rSEA in a hydrogel further enhanced type 2 immunity and larger volumes of tissue repair. The broad regenerative capacity of rSEA was validated in articular joint and corneal injury models. These results introduce a regenerative immunotherapy approach using natural helminth derivatives.

Funder

HHS | National Institutes of Health

U.S. Department of Defense

HHS | NIH | National Eye Institute

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2211703120

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