Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor-Reference-Cited by-同舟云学术

Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor

Published:1997-04-15 Issue:8 Volume:94 Page:3984-3989
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proceedings of the National Academy of Sciences

Author:

Esnouf R. M.,Ren J.,Hopkins A. L.,Ross C. K.,Jones E. Y.,Stammers D. K.,Stuart D. I.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Reference39 articles.

1. Toward Improved Anti-HIV Chemotherapy: Therapeutic Strategies for Intervention with HIV Infections

2. The Toxicity of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex

3. Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

4. Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative

5. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

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