A RhoA and Rnd3 cycle regulates actin reassembly during membrane blebbing

Author:

Aoki Kana1,Maeda Fumiyo1,Nagasako Tomoya2,Mochizuki Yuki1,Uchida Seiichi2,Ikenouchi Junichi134

Affiliation:

1. Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 819-0395, Japan;

2. Department of Advanced Information Technology, Kyushu University, Fukuoka 819-0395, Japan;

3. Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan;

4. AMED-PRIME, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan

Abstract

Significance The plasma membrane and the underlying actin cortex show dynamic interactions. When the plasma membrane detaches from the actin cortex, the plasma membrane protrudes. The protruded membrane is called a membrane bleb and is often observed during cell migration or cytokinesis. In the present study, we determined the molecular mechanisms involved in the reassembly of the actin cortex in membrane blebs using live-cell imaging.

Publisher

Proceedings of the National Academy of Sciences

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