ATR activity controls stem cell quiescence via the cyclin F–SCF complex-Reference-Cited by-同舟云学术

ATR activity controls stem cell quiescence via the cyclin F–SCF complex

Published:2022-04-27 Issue:18 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Salvi Jayesh S.¹²^ORCID,Kang Jengmin¹²^ORCID,Kim Soochi¹²^ORCID,Colville Alex J.¹²,de Morrée Antoine¹²^ORCID,Billeskov Tine Borum¹²^ORCID,Larsen Mikkel Christian¹²^ORCID,Kanugovi Abhijnya¹²,van Velthoven Cindy T. J.¹²,Cimprich Karlene A.³^ORCID,Rando Thomas A.¹²⁴

Affiliation:

1. Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305

2. Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305

3. Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305–5441

4. Neurology Service, VA Palo Alto Health Care System, Palo Alto, CA 94304

Abstract

Significance The replication stress response protein, ATR, is active in quiescent muscle stem cells in response to DNA:RNA hybrids, and this activity maintains quiescence by ensuring degradation of key cell-cycle transition factors by the E3 ubiquitin ligase cyclin F–SCF complex. This is critical for understanding how stem cells regulate a state of prolonged and reversible cell-cycle arrest and how genome integrity is maintained over time. Together, these studies offer a unique picture of a molecular mechanism controlling stem cell quiescence.

Funder

Human Frontier Science Program

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2115638119

Reference82 articles.

1. Molecular regulation of stem cell quiescence