Human defensin-inspired discovery of peptidomimetic antibiotics-Reference-Cited by-全球学者库

Human defensin-inspired discovery of peptidomimetic antibiotics

Published:2022-03 Issue:10 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Luo Gan¹,Zhang Jue¹^ORCID,Wang HanBin¹,Sun YaQi¹,Cheng BaoLi¹,Xu ZhiPeng¹,Zhang Yan²,Li Hui¹,Lu WuYuan³,Nemeth Elizabeta⁴^ORCID,Ganz Tomas⁴^ORCID,Fang XiangMing¹^ORCID

Affiliation:

1. Department of Anesthesiology and Intensive Care, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

2. National Clinical Research Center for Child Health, Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310052, China

3. Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China

4. Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095

Abstract

SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with highly inducible antibiotic resistance, promising a useful therapeutic agent for the treatment of infections caused by antibiotic-resistant bacteria.

Funder

Zhejiang University

National Natural Science Foundation of China

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2117283119

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