Prevention of the foreign body response to implantable medical devices by inflammasome inhibition-Reference-Cited by-同舟云学术

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

Published:2022-03-17 Issue:12 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Barone Damiano G.¹²³⁴^ORCID,Carnicer-Lombarte Alejandro¹⁴⁵,Tourlomousis Panagiotis³,Hamilton Russell S.⁶⁷^ORCID,Prater Malwina⁶⁷^ORCID,Rutz Alexandra L.⁴,Dimov Ivan B.⁴⁵,Malliaras George G.⁴^ORCID,Lacour Stephanie P.⁸^ORCID,Robertson Avril A. B.⁹^ORCID,Franze Kristian⁵¹⁰¹¹^ORCID,Fawcett James W.¹¹²,Bryant Clare E.³¹³^ORCID

Affiliation:

1. John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, United Kingdom

2. Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, United Kingdom

3. Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom

4. Electrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge CB3 0FA, United Kingdom

5. Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom

6. Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, United Kingdom

7. Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom

8. Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, 1202 Geneva, Switzerland

9. School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia

10. Max-Planck-Zentrum für Physik und Medizin, 91054 Erlangen, Germany

11. Institute of Medical Physics and Microtissue Engineering, Friedrich-Alexander University Erlangen–Nuremberg, 91052 Erlangen, Germany

12. Centre for Reconstructive Neuroscience, Institute for Experimental Medicine, Czech Academy of Sciences, 142 20 Prague 4, Czech Republic

13. Division of Medicine, University of Cambridge, Cambridge CB2 0PY, United Kingdom

Abstract

SignificanceImplantable electronic medical devices (IEMDs) are used for some clinical applications, representing an exciting prospect for the transformative treatment of intractable conditions such Parkinson’s disease, deafness, and paralysis. The use of IEMDs is limited at the moment because, over time, a foreign body reaction (FBR) develops at the device–neural interface such that ultimately the IEMD fails and needs to be removed. Here, we show that macrophage nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activity drives the FBR in a nerve injury model yet integration of an NLRP3 inhibitor into the device prevents FBR while allowing full healing of damaged neural tissue to occur.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2115857119

Reference59 articles.

1. Glial responses to implanted electrodes in the brain

2. Tissue‐Engineered Peripheral Nerve Interfaces

3. Novel electrode technologies for neural recordings

4. Foreign body reaction to biomaterials

5. A Review of the Foreign-body Response to Subcutaneously-implanted Devices: The Role of Macrophages and Cytokines in Biofouling and Fibrosis

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Fiber configuration determines foreign body response of electrospun scaffolds: in vitro and in vivo assessments;Biomedical Materials;2024-01-19

2. Implantable bioelectrodes: challenges, strategies, and future directions;Biomaterials Science;2024

3. Inflammasomes as regulators of mechano-immunity;EMBO Reports;2023-12-15

4. In vivo biocompatibility testing of nanoparticle-functionalized alginate–chitosan scaffolds for tissue engineering applications;Frontiers in Bioengineering and Biotechnology;2023-11-23

5. Bioengineered Conductive Scaffolds for Neural Tissue Engineering;Bioelectricity;2023-11-21