Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy-Reference-Cited by-同舟云学术

Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy

Published:2022-02-03 Issue:6 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Ayers Jacob I.¹²^ORCID,Lee Joanne¹^ORCID,Monteiro Octovia¹,Woerman Amanda L.¹²^ORCID,Lazar Ann A.³⁴,Condello Carlo¹²,Paras Nick A.¹²,Prusiner Stanley B.¹²⁵^ORCID

Affiliation:

1. Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158

2. Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158

3. Division of Biostatistics, University of California, San Francisco, CA 94158

4. Division of Oral Epidemiology and Dental Public Health, University of California, San Francisco, CA 94143

5. Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158

Abstract

Significance Dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) are caused by α-synuclein prions that differ from each other and from those causing Parkinson’s disease (PD). DLB prions differ in their infectivity from those causing MSA or PD. The wild-type, normal version of the α-synuclein protein has the acidic amino acid glutamate (E) at residue 46, while in cases of inherited PD, it is mutated to the basic amino acid lysine (K). Using genetically engineered α-synuclein, we identified unique conditions for propagating MSA and DLB prions. Being able to distinguish among strains of naturally occurring α-synuclein prions may make it possible to develop strain-specific therapeutics for MSA, DLB, and PD.

Funder

HHS | NIH | National Institute on Aging

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2113489119

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