Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome-Reference-Cited by-同舟云学术

Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome

Published:2022-03-09 Issue:11 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Winkler Juliane¹²^ORCID,Liu Pengyuan³⁴,Phong Kiet⁵,Hinrichs Johanna H.¹⁶,Ataii Nassim¹,Williams Katherine³,Hadler-Olsen Elin¹⁷^ORCID,Samson Susan¹²,Gartner Zev J.⁵⁸⁹,Fisher Susan¹³^ORCID,Werb Zena¹

Affiliation:

1. Department of Anatomy, University of California, San Francisco, CA 94143

2. Department of Cell and Tissue Biology, University of California, San Francisco, CA 94143

3. Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143

4. Department of Chemistry, University of Massachusetts, Lowell, MA 01854

5. Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158

6. Institute of Internal Medicine D, Medical Cell Biology, University Hospital Münster, 08154 Münster, Germany

7. Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway

8. The Center for Cellular Construction, University of California, San Francisco, CA 94158

9. Chan Zuckerberg Biohub Investigator, University of California, San Francisco, CA 94158

Abstract

Significance Bisphenol A (BPA), found in many plastic products, has weak estrogenic effects that can be harmful to human health. Thus, structurally related replacements—bisphenol S (BPS) and bisphenol F (BPF)—are coming into wider use with very few data about their biological activities. Here, we compared the effects of BPA, BPS, and BPF on human mammary organoids established from normal breast tissue. BPS disrupted organoid architecture and induced supernumerary branching. At a proteomic level, the bisphenols altered the abundance of common targets and those that were unique to each compound. The latter included proteins linked to tumor-promoting processes. These data highlighted the importance of testing the human health effects of replacements that are structurally related to chemicals of concern.

Funder

California Breast Cancer Research Program

European Molecular Biology Organization

Deutscher Akademischer Austauschdienst

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2115308119

Reference83 articles.

1. Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

2. Analytical methods for the determination of mixtures of bisphenols and derivatives in human and environmental exposure sources and biological fluids. A review

3. Exposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004

4. CDC “Fourth national report on human exposure to environmental chemicals: Updated tables Volume 2 NHANES 2011–2016” (Rep. Centers for Disease Control and Prevention Atlanta GA 2019).

5. Molecular Mechanisms of Action of BPA

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