p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1-Reference-Cited by-全球学者库

p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1

Published:2022-05-26 Issue:22 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Laubach Kyra Nicole¹,Yan Wensheng¹,Kong Xiangmudong¹,Sun Wenqiang¹,Chen Mingyi²^ORCID,Zhang Jin¹,Chen Xinbin¹

Affiliation:

1. Comparative Oncology Laboratory, Schools of Medicine and Veterinary Medicine, University of California, Davis, CA 95616

2. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390

Abstract

Significance p73 is expressed as multiple C-terminal isoforms, but their expression and activity are largely unknown. Here, we identified p73α1 as a p73 C-terminal isoform that results from exon 12 ( E12 ) exclusion. We showed that E12 deficiency in mice leads to systemic inflammation but not spontaneous tumors. We also showed that Notch1 is regulated by p73α1 and plays a critical role in p73-dependent tumor suppression and systemic inflammation.

Funder

HHS | NIH | Office of Extramural Research, National Institutes of Health

Tobacco-Related Disease Research Program

HHS | NIH | National Cancer Institute

UC | University of California, Davis

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2123202119

Reference80 articles.