Orc6 is a component of the replication fork and enables efficient mismatch repair-Reference-Cited by-同舟云学术

Orc6 is a component of the replication fork and enables efficient mismatch repair

Published:2022-05-27 Issue:22 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Lin Yo-Chuen¹,Liu Dazhen¹,Chakraborty Arindam¹,Kadyrova Lyudmila Y.²,Song You Jin¹,Hao Qinyu¹,Mitra Jaba³^ORCID,Hsu Rosaline Y. C.¹^ORCID,Arif Mariam K.¹,Adusumilli Sneha¹^ORCID,Liao Ting-Wei³,Ha Taekjip³⁴^ORCID,Kadyrov Farid A.²,Prasanth Kannanganattu V.¹⁵,Prasanth Supriya G.¹⁵

Affiliation:

1. Department of Cell and Developmental Biology, University of Illinois at Urbana–Champaign, Urbana, IL 61801

2. Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901

3. Biophysics and Biophysical Chemistry, Johns Hopkins University, Baltimore, MD 21205

4. HHMI, Johns Hopkins University, Baltimore, MD 21205

5. Cancer Center at Illinois, University of Illinois at Urbana–Champaign, Urbana, IL 61801

Abstract

Significance Origin recognition complex (ORC) is required for the initiation of DNA replication. Unlike other ORC components, the role of human Orc6 in replication remains to be resolved. We identified an unexpected role for hOrc6, which is to promote S-phase progression after prereplication complex assembly and DNA damage response. Orc6 localizes at the replication fork, is an accessory factor of the mismatch repair complex, and plays a fundamental role in genome surveillance during S phase.

Funder

National Science Foundation

HHS | NIH | National Institute of General Medical Sciences

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2121406119

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