Translatable tool to quantitatively assess the quality of red blood cell units and tailored cultured red blood cells for transfusion

Author:

Kaestner Lars12ORCID,Schlenke Peter3,von Lindern Marieke45ORCID,El Nemer Wassim6

Affiliation:

1. Theoretical Medicine and Biosciences, Saarland University, Campus Saarland University Hospital, Homburg/Saar 66424, Germany

2. Dynamics of Fluids, Experimental Physics, Saarland University, Saarbruecken 66123, Germany

3. Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz 8036, Austria

4. Landsteiner Laboratory, Amsterdam University Medical Center, University of Amsterdam, Amsterdam 1105AZ, The Netherlands

5. Department Hematopoiesis, Sanquin Blood Supply Foundation, Amsterdam 1066CX, The Netherlands

6. Etablissement Français du Sang Prevence Alpes Côte d’Azur-Corse, Aix Marseille University, Centre national de la recherche scientifique (CNRS), Anthropologie bio-culturelle, Droit, Ethique et Santé (UMR 7268), Globule Rouge laboratory of excellence (GR-Ex), Marseille 13005, France

Funder

European Community

Publisher

Proceedings of the National Academy of Sciences

Reference10 articles.

1. Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine

2. World Health Organization “Global status report on blood safety and availability 2021” (World Health Organisation Geneva Switzerland 2022).

3. European Commission Safety Directorate-General for Health and Food “Proposal for a Regulation of the European Parliament and of the council on standards of quality and safety for substances of human origin intended for human application and repealing directives 2002/98/EC and 2004/23/EC” (Document 52022PC0338 European Commission Brussels Belgium 2022).

4. Erysense, a Lab-on-a-Chip-Based Point-of-Care Device to Evaluate Red Blood Cell Flow Properties With Multiple Clinical Applications

5. Classification of red blood cell shapes in flow using outlier tolerant machine learning

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