Remodeling<i>Yersinia pseudotuberculosis</i>to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague-Reference-Cited by-同舟云学术

RemodelingYersinia pseudotuberculosisto generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague

Published:2022-03-11 Issue:11 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Wang Xiuran¹^ORCID,Li Peng¹^ORCID,Singh Amit K.¹^ORCID,Zhang Xiangmin²,Guan Ziqiang³^ORCID,Curtiss Roy⁴,Sun Wei¹^ORCID

Affiliation:

1. Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208

2. Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy/Health Sciences, Wayne State University, Detroit, MI 48201

3. Department of Biochemistry, Duke University Medical Center, Durham, NC 27710

4. Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611

Abstract

SignificanceYersinia pestis, the etiologic agent of plague, has been responsible for high mortality in several epidemics throughout human history. This plague bacillus has been used as a biological weapon during human history and is currently one of the deadliest biological threats. Currently, no licensed plague vaccines are available in the Western world. Since an array of immunogens are enclosed in outer membrane vesicles (OMVs), immune responses elicited by OMVs against a diverse range of antigens may reduce the likelihood of antigen circumvention. Therefore, self-adjuvanting OMVs from a remodeledYersinia pseudotuberculosisstrain as a type of plague vaccine could diversify prophylactic choices and solve current vaccine limitations.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2109667119

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