Extracellular vesicles from triple negative breast cancer promote pro-inflammatory macrophages associated with better clinical outcome-Reference-Cited by-同舟云学术

Extracellular vesicles from triple negative breast cancer promote pro-inflammatory macrophages associated with better clinical outcome

Published:2022-04-19 Issue:17 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Tkach Mercedes¹,Thalmensi Jessie¹,Timperi Eleonora¹,Gueguen Paul¹^ORCID,Névo Nathalie¹^ORCID,Grisard Eleonora¹^ORCID,Sirven Philemon¹,Cocozza Federico¹^ORCID,Gouronnec Alizée¹,Martin-Jaular Lorena¹^ORCID,Jouve Mabel²^ORCID,Delisle Fabien¹,Manel Nicolas¹^ORCID,Rookhuizen Derek C.¹,Guerin Coralie L.³⁴^ORCID,Soumelis Vassili⁵⁶,Romano Emanuela¹^ORCID,Segura Elodie¹^ORCID,Théry Clotilde¹^ORCID

Affiliation:

1. INSERM U932, Institut Curie, PSL Research University, 75005, Paris, France

2. CNRS UMR3215, Institut Curie, PSL Research University, 75005, Paris, France

3. Cytometry Platform, CurieCoreTech, Institut Curie, Paris, F-75005 France

4. Innovative Therapies in Haemostasis, INSERM, Université de Paris, Paris, F-75006 France

5. Université de Paris, Inserm, U976 HIPI Unit, F-75006, Paris, France

6. Assistance Publique-Hôpitaux de Paris (AP-HP), Laboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, F-75010, Paris, France

Abstract

Significance Our work uncovers mechanisms by which tumor cells impact tumor-associated macrophages in human triple-negative breast cancer. Via extracellular vesicles (EVs), these tumors promote macrophages with proinflammatory features, correlated with better clinical outcome. Our results suggest exploration of these EVs as tools, alone, or in combination with other therapies, to promote a favorable environment for the generation of anti-tumor immune responses.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2107394119

Reference72 articles.

1. Targeting macrophages: therapeutic approaches in cancer

2. Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

3. An Immune Atlas of Clear Cell Renal Cell Carcinoma

4. Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

5. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

Cited by 59 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Effect of tumor-derived extracellular vesicle-shuttled lncRNA MALAT1 on proliferation, invasion and metastasis of triple-negative breast cancer by regulating macrophage M2 polarization via the POSTN/Hippo/YAP axis;Translational Oncology;2024-11

2. Chimeric antigen receptor (CAR) T-cell therapy: Harnessing extracellular vesicles for enhanced efficacy;Pharmacological Research;2024-10

3. Tumor‑associated macrophages activated in the tumor environment of hepatocellular carcinoma: Characterization and treatment (Review);International Journal of Oncology;2024-09-05

4. Tumor-associated macrophages: orchestrators of cholangiocarcinoma progression;Frontiers in Immunology;2024-09-03

5. Plasma extracellular vesicles proteomics in meningioma patients;Translational Oncology;2024-09