Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs-Reference-Cited by-同舟云学术

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs

Published:2015-02-23 Issue:10 Volume:112 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Londin Eric¹,Loher Phillipe¹,Telonis Aristeidis G.¹,Quann Kevin¹,Clark Peter¹,Jing Yi¹,Hatzimichael Eleftheria¹²,Kirino Yohei¹,Honda Shozo¹,Lally Michelle³,Ramratnam Bharat³,Comstock Clay E. S.⁴^ORCID,Knudsen Karen E.⁵,Gomella Leonard⁵,Spaeth George L.⁶,Hark Lisa⁶,Katz L. Jay⁶,Witkiewicz Agnieszka⁷,Rostami Abdolmohamad⁸,Jimenez Sergio A.⁹,Hollingsworth Michael A.¹⁰,Yeh Jen Jen¹¹,Shaw Chad A.¹²,McKenzie Steven E.¹³,Bray Paul¹³,Nelson Peter T.¹⁴,Zupo Simona¹⁵,Van Roosbroeck Katrien¹⁶,Keating Michael J.¹⁷,Calin George A.¹⁷,Yeo Charles¹⁸,Jimbo Masaya¹⁸,Cozzitorto Joseph¹⁸,Brody Jonathan R.¹⁸,Delgrosso Kathleen¹⁹,Mattick John S.²⁰²¹,Fortina Paolo¹⁹,Rigoutsos Isidore¹

Affiliation:

1. Computational Medicine Center, Sidney Kimmel Medical School at Thomas Jefferson University, Philadelphia, PA 19107;

2. Department of Hematology, University Hospital of Ioannina, Ioannina, GR-45500, Greece;

3. Department of Medicine, Rhode Island and Miriam Hospitals, Alpert Medical School of Brown University, Providence, RI 02912;

4. American Association of Cancer Research, Philadelphia, PA 19106;

5. Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107;

6. Glaucoma Service, Wills Eye Institute, Philadelphia, PA 19107;

7. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235;

8. Department of Neurology, Sidney Kimmel Medical School at Thomas Jefferson University, Philadelphia, PA 19107;

9. Jefferson Institute of Molecular Medicine and The Scleroderma Center, Sidney Kimmel Medical School at Thomas Jefferson University, Philadelphia, PA 19107;

10. Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198;

11. Departments of Surgery and Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514;

12. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030;

13. Cardeza Foundation for Hematologic Research, Division of Hematology, Department of Medicine, Sidney Kimmel Medical School at Thomas Jefferson University, Philadelphia, PA 19107;

14. Department of Pathology, Division of Neuropathology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506;

15. Molecular Diagnostic Laboratory, Pathology Department, Istituto di Ricovero e Cura a Carattere Scientifico, Azienda Ospedaliera Universitaria San Martino IST, Genoa, Italy;

16. Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77030;

17. Leukemia Department, University of Texas MD Anderson Cancer Center, Houston, TX 77030;

18. Department of Surgery, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia PA 19107;

19. Cancer Genomics Laboratory, Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107;

20. Garvan Institute of Medical Research, Sydney NSW 2010, Australia; and

21. St. Vincent's Clinical School and School of Biotechnology & Biomolecular Sciences, University of New South Wales, Sydney NSW 2052, Australia

Abstract

Significance MicroRNAs (miRNAs) are small ∼22-nt RNAs that are important regulators of posttranscriptional gene expression. Since their initial discovery, they have been shown to be involved in many cellular processes, and their misexpression is associated with disease etiology. Currently, nearly 2,800 human miRNAs are annotated in public repositories. A key question in miRNA research is how many miRNAs are harbored by the human genome. To answer this question, we examined 1,323 short RNA sequence samples and identified 3,707 novel miRNAs, many of which are human-specific and tissue-specific. Our findings suggest that the human genome expresses a greater number of miRNAs than has previously been appreciated and that many more miRNA molecules may play key roles in disease etiology.

Publisher

Proceedings of the National Academy of Sciences

Link

https://pnas.org/doi/pdf/10.1073/pnas.1420955112

Reference74 articles.

1. MicroRNAs: Genomics, biogenesis, mechanism, and function;Bartel DP;Cell,2004

2. MicroRNAs: Target recognition and regulatory functions;Bartel DP;Cell,2009

3. miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay;Djuranovic S;Science,2012

4. Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing;Eulalio A;Genes Dev,2007

5. Principles of microRNA regulation of a human cellular signaling network;Cui Q;Mol Syst Biol,2006

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