Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors-Reference-Cited by-同舟云学术

Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors

Published:2024-03 Issue:3 Volume:132 Page:
ISSN:0091-6765
Container-title:Environmental Health Perspectives
language:en
Short-container-title:Environ Health Perspect

Author:

Niemeijer Marije¹^ORCID,Więcek Witold²,Fu Shuai²,Huppelschoten Suzanna¹,Bouwman Peter¹,Baze Audrey³,Parmentier Céline³,Richert Lysiane³⁴,Paules Richard S.⁵,Bois Frederic Y.²,van de Water Bob¹

Affiliation:

1. Division of Drug Discovery and Safety, LACDR, Leiden University, Leiden, The Netherlands

2. Simcyp Division, CERTARA, Sheffield, UK

3. KaLy-Cell, Plobsheim, France

4. Zylan, Obernai, France

5. Division of the National Toxicology Program, NIEHS, NIH, Research Triangle Park, North Carolina, USA

Publisher

Environmental Health Perspectives

Link

https://ehp.niehs.nih.gov/doi/pdf/10.1289/EHP11891

Reference71 articles.

1. Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals

2. Drug Safety Sciences and the Bottleneck in Drug Development

3. Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease

4. Environmental Risk Factors Implicated in Liver Disease: A Mini-Review

5. Environmental toxicant-induced maladaptive mitochondrial changes: A potential unifying mechanism in fatty liver disease?

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