Application of the Key Characteristics Framework to Identify Potential Breast Carcinogens Using Publicly Available in Vivo , in Vitro , and in Silico Data

Author:

Kay Jennifer E.1ORCID,Brody Julia Green1,Schwarzman Megan23,Rudel Ruthann A.1

Affiliation:

1. Silent Spring Institute, Newton, Massachusetts, USA

2. School of Public Health, University of California, Berkeley, Berkeley, California, USA

3. Family and Community Medicine, University of California, San Francisco, San Francisco, California, USA

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference190 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

2. SEER (Surveillance Epidemiology and End Results Program) NCI (National Cancer Institute). 2023. SEER*Explorer: breast cancer. Last updated 19 April 2023. https://seer.cancer.gov/statistics-network/explorer/application.html?site=55&data_type=1&graph_type=2&compareBy=sex&chk_sex_3=3&chk_sex_2=2&rate_type=2&race=1&age_range=1&stage=101&advopt_precision=1&advopt_show_ci=on&hdn_view=0&advopt_show_apc=on&advopt_display=2#resultsRegion0 [accessed 19 April 2023].

3. Cancer statistics, 2022

4. Annual Report to the Nation on the Status of Cancer, Featuring Cancer in Men and Women Age 20–49 Years

5. Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast

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