In vitro and in vivo genotoxicity of 1,3-butadiene and metabolites.

Author:

Arce G T1,Vincent D R1,Cunningham M J1,Choy W N1,Sarrif A M1

Affiliation:

1. Haskell Laboratory for Toxicology and Industrial Medicine, E. I. du Pont de Nemours & Company, Inc., Newark, DE 19714.

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference30 articles.

1. NTP. Toxicology and Carcinogenesis Studies of 1 3-Butadiene (CAS No. 106-99-0) in B6C3F1 Mice (Inhalation Studies). Technical Report 288. National Toxicology Program Research Triangle Park NC 1984.

2. Multiple Organ Carcinogenicity of 1,3-Butadiene in B6C3F 1 Mice After 60 Weeks of Inhalation Exposure

3. Hazelton Laboratories Europe Ltd. The Toxicity and Carcinogenicity of Butadiene Gas Administered to Rats by Inhalation for Approximately 24 Months. Report No. 2653-522/2. Hazelton Laboratories Europe Ltd. Harrowgate England 1981.

4. Species differences in the disposition of inhaled butadiene

5. Biological activation of 1,3-butadiene to vinyl oxirane by rat liver microsomes and expiration of the reactive metabolite by exposed rats

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