Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis

Author:

Gruzieva Olena12,Xu Cheng-Jian345,Yousefi Paul67,Relton Caroline67,Merid Simon Kebede1,Breton Carrie V.8,Gao Lu8,Volk Heather E.910,Feinberg Jason I.9,Ladd-Acosta Christine11,Bakulski Kelly11,Auffray Charles12,Lemonnier Nathanaël1213,Plusquin Michelle1415,Ghantous Akram16,Herceg Zdenko16,Nawrot Tim S.1417,Pizzi Costanza18,Richiardi Lorenzo18,Rusconi Franca19,Vineis Paolo15,Kogevinas Manolis2021,Felix Janine F.2223,Duijts Liesbeth2224,den Dekker Herman T.2223,Jaddoe Vincent W. V.2223,Ruiz José L.2526,Bustamante Mariona202125,Antó Josep Maria202127,Sunyer Jordi202127,Vrijheid Martine2021,Gutzkow Kristine B.28,Grazuleviciene Regina29,Hernandez-Ferrer Carles2030,Annesi-Maesano Isabella31,Lepeule Johanna32,Bousquet Jean3334,Bergström Anna12,Kull Inger13536,Söderhäll Cilla3738,Kere Juha3839,Gehring Ulrike40,Brunekreef Bert4041,Just Allan C.42,Wright Rosalind J.43,Peng Cheng44,Gold Diane R.4445,Kloog Itai46,DeMeo Dawn L.44,Pershagen Göran12,Koppelman Gerard H.34,London Stephanie J.47,Baccarelli Andrea A.48,Melén Erik136,

Affiliation:

1. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

2. Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden

3. Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Netherlands

4. Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, Beatrix Children's Hospital, University of Groningen, Netherlands

5. Department of Genetics, University Medical Center Groningen, University of Groningen, Netherlands

6. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK

7. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK

8. Department of Preventive Medicine, University of Southern California Los Angeles, Los Angeles, California, USA

9. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

10. Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

11. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA

12. European Institute for Systems Biology and Medicine (EISBM), CNRS-ENS-UCBL, Université de Lyon, Lyon, France

13. Institute for Advanced Biosciences, UGA-Institut national de la santé et de la recherché médicale (Inserm), La Tronche, France

14. Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium

15. MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK

16. Epigenetics Group, International Agency for Research on Cancer, Lyon, France

17. Department of Public Health & Primary Care, Leuven University, Leuven, Belgium

18. Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte, Turin, Italy

19. Unit of Epidemiology, Meyer Children's University Hospital, Florence, Italy

20. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain

21. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

22. Generation R Study Group, Erasmus MC (Medical Centre), University Medical Center Rotterdam, Rotterdam, Netherlands

23. Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

24. Department of Pediatrics, Divisions of Respiratory Medicine and Allergology, and Neonatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands

25. Center for Genomic Regulation (CRG), Barcelona, Spain

26. Instituto de Parasitología y Biomedicina López-Neyra (IPBLN), Spanish National Research Council (CSIC), Armilla, Granada, Spain

27. Hospital de Mar Medical Research Institute (IMIM), Barcelona, Spain

28. Norwegian Institute of Public Health, Oslo, Norway

29. Department of Environmental Sciences, Vytauto Didziojo Universitetas, Kaunas, Lithuania

30. Computational Health Informatics Program, Boston Children’s Hospital, Boston, Massachusetts, USA

31. Epidemiology of Allergic and Respiratory Diseases Department, IPLESP, Inserm and Sorbonne University Medical School Saint-Antoine, Paris, France

32. Université Grenoble Alpes, Inserm, National Institute of Health & Medical Research, CNRS, IAB, Grenoble, France

33. Innovation Partnership on Active and Healthy Ageing Reference Site, MACVIA-France (Contre les Maladies Chroniques pour un Vieillissement Actif en France European), Montpellier, France

34. U 1168, VIMA: Ageing and Chronic Diseases Epidemiological and Public Health Approaches, Inserm Villejuif, Université Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, France

35. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden

36. Sachs Children’s Hospital, Stockholm, Sweden

37. Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden

38. Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden

39. School of Basic and Medical Biosciences, King’s College London, Guy’s Hospital, London, UK

40. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands

41. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

42. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, USA

43. Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, USA

44. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

45. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

46. Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel

47. National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, USA

48. Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, USA

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

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