Author:
SCHÜßLER P.,KÖHRER K.,FINKEN-EIGEN M.,MICHEL A.,GREVELDING C. G.,KUNZ W.
Abstract
A female-specifically expressed cDNA clone was obtained
by screening of a subtractive cDNA library enriched for RNA
from Schistosoma mansoni females. The deduced
protein shows significant homology to a class of enzymes
functioning as amidases. Northern blots revealed a transcript
of 4·0 kb which is absent in larval stages, but is
expressed in adult female
worms. By in situ hybridization, the expression site
of the gene was exclusively localized in the gastrodermis of female
schistosomes. This is the first report of a female-specifically
transcribed sequence of S. mansoni that is not
expressed in the reproductive organs.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Animal Science and Zoology,Parasitology
Cited by
7 articles.
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