Studies of antigens inPlasmodium yoelii

Author:

Panton Lindsey J.,Knowles G.,Walliker D.

Abstract

SummaryAntigens of three lines of the rodent malaria parasitePlasmodium yoeliihave been studied using crossed immunoelectrophoresis.P. y. yoeliiline A1is a mild line which is restricted to reticulocytes.P. y. yoeliiline YM andP. y. nigeriensisline D1are virulent infections which multiply in both immature and mature erythrocytes. One antigen, designated Py-1, was found to differ in its electrophoretic mobility between the lines, being fast (F) in lines A1and YM and slow (S) in line D1. Antigen Py-1 also varied in quantity among the three lines; greater amounts were detected in parasites inhabiting mature erythrocytes than in those in reticulocytes. These characters were stable during blood and mosquito passage.

Publisher

Cambridge University Press (CUP)

Subject

Infectious Diseases,Animal Science and Zoology,Parasitology

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