Author:
Yang Qiong,Huang Xuebing,Hong Nan,Yu Xin
Abstract
Objective: To evaluate the location and the degree of white matter damage in late-life depression using diffusion tensor imaging (DTI).Methods: Thirty-one patients with late-life depression and 15 healthy volunteers matched for age, gender and years of education received conventional MRI (magnetic resonance imaging) and MR-diffusion tensor scanning. The fractional anisotropy (FA) values of white matter were measured respectively in frontal and temporal regions and the corpus callosum.Results: FA values were significantly decreased in the frontal (superior and middle frontal gyrus), and temporal (right parahippocampal gyrus) regions of elderly patients with depression compared with healthy controls.Conclusion: Microstructural changes in the frontal (superior and middle frontal gyrus) and temporal (right parahippocampal gyrus) areas are associated with late-life depression.
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Geriatrics and Gerontology,Gerontology,Clinical Psychology
Cited by
83 articles.
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