Author:
Beking Kristopher,Vieira Amandio
Abstract
AbstractObjectiveDietary flavonoids and their metabolites may have neuroprotective effects against age-associated neurodegenerative disorders such as Alzheimer’s and related dementias (dementia). There is a lack of population studies, however, on correlations between flavonoid intake and dementia. The main objective of the present study was to analyse such a relationship at a large-scale population level.DesignBased on global data (FAO, WHO), databases were generated for: (i) flavonoid content of foods; (ii) per capita national dietary intakes of flavonoids and other dietary factors; and (iii) disability-adjusted life years – a measure of burden and death – due to dementia. Five major flavonoid subclasses were examined. To minimize influences due to accuracy and reliability of the disease source data, twenty-three developed countries were selected after statistical evaluation.ResultsFlavonols and combined flavonoids (all five combined) intakes were the only two parameters with significant (P < 0·05) negative dementia correlations. Multiple linear regression models confirmed this relationship, and excluded confounding from some other dietary and non-dietary factors. Similar analyses with non-dementia, neurological/psychiatric diseases did not yield significant correlations.ConclusionsAt a global level, and in the context of different genetic backgrounds, our results suggest that higher consumption of dietary flavonoids, especially flavonols, is associated with lower population rates of dementia in these countries.
Publisher
Cambridge University Press (CUP)
Subject
Public Health, Environmental and Occupational Health,Nutrition and Dietetics,Medicine (miscellaneous)
Reference57 articles.
1. Tea consumption and cognitive impairment and decline in older Chinese adults
2. Chocolate contains additional flavonoids not found in tea;Arts;Lancet,1999
3. Antioxidant flavonols and coronary heart disease risk
4. Mediterranean diet and mild cognitive impairment;Scarmeas;Arch Neurol,2009
5. 27. Central Intelligence Agency (2007) Field Listing – Sex Ratio. The World Factbook. https://www.cia.gov/library/publications/the-world-factbook/fields/2018.html (accessed October 2007).
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