Author:
Bergerot Cristiane Decat,Clark Karen Lynn,Nonino Alexandre,Waliany Sarah,Buso Marco Murilo,Loscalzo Matthew
Abstract
AbstractObjective:The aim of our study was to explore the impact of gender and hematological cancer grade on distress, anxiety, and depression in patients receiving chemotherapy.Methods:A prospective study was done in a cohort of 104 patients with hematological cancer. We employed the (1) Distress Thermometer (DT) and the Problem List (PL) and (2) the Hospital Anxiety and Depression Scale (HADS) for assessments at baseline (T1), the halfway timepoint (T2), and completion of chemotherapy (T3).Results:The proportion of patients experiencing significant distress (DT ≥ 4) decreased from the first to the last timepoint; the proportion experiencing anxiety and depression (as assessed by HADS) also decreased. Specifically, 50% of participants reported significant distress levels, 47.1% anxiety, and 26% depression at T1. At T2, the proportion of patients experiencing distress was reduced by 60.8%, by 76% for anxiety, and by 48.5% for depression; at T3, the reduction was close to 80% for all assessments compared with T1. Emotional and physical problems were most commonly reported. Significant reductions were discovered for distress and problem-related distress levels over time, and a significant interaction was found between gender and practical and physical problems (p < 0.05).Significance of results:Our findings suggest that female patients reported more distress, anxiety, and depression than male patients. Gender differences were related to problem-related distress but not to grade of neoplasm. We observed that, over the course of chemotherapy, the distress levels of patients with hematological cancer decrease over time.
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Clinical Psychology,General Medicine,General Nursing
Reference28 articles.
1. Predictors of change in unmet supportive care needs in cancer
2. WHO International Agency for Research on Cancer. (2008). Globocan 2008: Cancer incidence, mortality and prevalence worldwide in 2008. Available from http://globocan.iarc.fr.
3. Psychiatric Morbidity and Impact on Hospital Length of Stay Among Hematologic Cancer Patients Receiving Stem-Cell Transplantation
4. Screening for distress, the sixth vital sign: Common problems in cancer outpatients over one year in usual care: Associations with marital status, sex, and age;Giese-Davis;BioMed Central Cancer,2012