Affiliation:
1. Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia
Abstract
The most common viral infections causing gastroenteritis in children include rotavirus, norovirus, and the SARS-CoV-2. A typical clinical picture includes fever, vomiting, diarrhea, toxicosis and exicosis of varying severity. However, in 30—35% of cases, acute intestinal infections of viral etiology complicate of acute kidney injury (AKI), which significantly aggravates the course of the disease and affects the outcome of the disease. Currently used markers for the diagnosis of AKI are poor informative due to late detection of typical laboratory changes during the clinical picture's change. Currently, there are non-invasive biomarkers of AKI detected before changes in routine biochemical tests and can be used for early diagnosis of kidney damage. Using of these biomarkers in practice will develop of clinical and laboratory differential diagnostic criteria for early diagnosis, risk factors for the development of AKI in children with viral diarrhea of various agents, in order to start timely effective pathogenetic treatment and prevent serious complications.
Publisher
Journal of Childrens Infections
Reference57 articles.
1. World Health Organization. Diarrhoeal disease. Rotavirus infection 2018. Available at: https://cdn.who.int/media/docs/default-source/immunization/vpd_surveillance/vpd-surveillance-standards-publication/19-who-surveillancevaccinepreventable-19-rotavirus-russianr1.pdf?sfvrsn=2c43bf06_10&download=true
2. On the state of sanitary and epidemiological well-being of the population in the Russian Federation in 2021: State report. M.: Federal Service for Supervision of Consumer Rights Protection and Human Welfare, 2022:340. (In Russ.)
3. Samitova E.R. Clinical and Epidemiological Features of COVID-19 in Children in Moscow in 2020—2022. Epidemiology and Vaccinal Prevention. 2022; 21(5):38—48. (In Russ.) https://doi.org/10.31631/20733046-2022-21-5-38-48
4. Shchikota A.M., Pogonchenkova I.V., Turova E.A., Starodubova A.V., Nosova N.V. COVID-19-associated diarrhea. Voprosy pitaniia [Problems of Nutrition]. 2021; 90(6):18—30. (in Russ.) https://doi.org/10.33029/0042-8833-2021-90-6-18-30
5. D'Amico F, Baumgart DC, Danese S, Peyrin-Biroulet L. Diarrhea During COVID-19 Infection: Pathogenesis, Epidemiology, Prevention, and Management. Clin Gastroenterol Hepatol. 2020 Jul;18(8):1663—1672. doi: 10.1016/j.cgh.2020.04.001.