In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm

Author:

Artigas Laura,Coma Mireia,Matos-Filipe Pedro,Aguirre-Plans JoaquimORCID,Farrés Judith,Valls Raquel,Fernandez-Fuentes Narcis,de la Haba-Rodriguez Juan,Olvera Alex,Barbera Jose,Morales Rafael,Oliva BaldoORCID,Mas Jose Manuel

Funder

Ministerio de Ciencia, Innovación y Universidades

H2020 Marie Skłodowska-Curie Actions

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference97 articles.

1. Shen S, Woo R. Coronavirus incubation could be as long as 27 days, Chinese provincial government says. In: Reuters [Internet]. 2020 [cited 2 Apr 2020]. Available: https://es.reuters.com/article/idUKKCN20G072

2. Centers for Disease Control and Prevention (CDC). Symptoms of Coronavirus Disease 2019 (COVID-19) | CDC. In: Centers for Disease Control and Prevention (CDC) [Internet]. 2020 [cited 2 Apr 2020]. Available: https://www.cdc.gov/coronavirus/2019-ncov/about/symptoms.html

3. Clinical trials on drug repositioning for COVID-19 treatment.;SG Viveiros Rosa;PAJPH.,2020

4. Hopes rise for coronavirus drug remdesivir;H. Ledford;Nature,2020

5. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing;DE Gordon;Nature,2020

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